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JAMA. 1937;109(10):797. doi:10.1001/jama.1937.02780360045014.
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VITAMIN C AND PYORRHEA ALVEOLARIS  Pyorrhea may be one of two types: a local inflammatory disease, beginning at the gingival margin, or a diffuse atrophic disease of systemic origin. According to Boyle and his co-workers,1 systemic pyorrhea alveolaris may be readily produced in guinea-pigs by vitamin C deficiency. Within six months after guineapigs have been placed on a vitamin C free diet, loosening and wandering of the teeth are demonstrable.X-ray studies of sagittal sections of the heads reveal marked rarefactions of the alveolar bone with widening of the periodontal membrane. The microscopic details are identical with those found in human periodontal disease of the atrophic type. Similar changes take place at a slower rate in guinea-pigs maintained for many months on a relatively low cevitamic acid intake. They have not yet studied the effectiveness of vitamin C therapy as a cure of experimental pyorrhea, nor has the alleged

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