This monograph presents a rather complete review of the work on the relation of the stomach to the production of the anti-pernicious anemia substance. The subject matter is discussed under gastric preparations and their therapeutic effect in pernicious anemia, action of gastric juice, action of stomach extracts, the effect of gastric resection, the physiologic anatomy of the stomach and the anti-pernicious anemia principle. Rambert reports his own experiments on the effect of the injection of gastric juice into rats as a test for the presence of anti-pernicious anemia substance. He also confirms the work of Singer, who first described this procedure. The bibliography of 388 articles is well chosen. The material is presented in an easily readable form and should serve as a convenient summary for investigators working in this field.