This volume is prefaced by a photogravure of Edward Jenner worthy of a place as an adornment in any medical office. The manuscript notebook of the great founder of modern immunology came into possession of the Royal College of Physicians in 1888. The manuscript consists of a notebook of eighty pages, some of which are blank. It covers the period from 1787 to 1806 and records observations made by Jenner concerning the habits of the cuckoo, the presence of hydatids in the bodies of various animals, and distemper in dogs. Edward Jenner was a naturalist as well as a physician. He made many necropsies on dogs that had died of distemper, his one important conclusion being that the lungs are often the seat of extensive inflammation. The book includes not only an exact transcription in good type of the contents of the book but also an appreciative essay by Dr.