The author, who is known for his arterial encephalography, has ventured again into a radical diagnostic and therapeutic procedure. On the assumption that certain psychoses are due to congenital malformations of the frontal association fibers, he attempts to destroy these abnormal fibers by injecting alcohol into the white matter of the frontal lobes. He avoids producing paralysis or aphasia. His results have been encouraging to him, although, as he states, the patients are not always intellectually the same after the treatment. A good deal more work must be done experimentally before the procedure can be utilized in this country. The basis for the treatment is incomprehensible to us and we should demand much more empirical data before even thinking of using this extremely radical procedure.