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Arthur J. Geiger, M.D.; Louis S. Goodman, M.D.
JAMA. 1937;108(20):1733. doi:10.1001/jama.1937.02780200055023.
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To the Editor:—  A publication by H. S. Rubinstein in the Archives of Neurology and Psychiatry for March on the use of trichlorethylene in the treatment of migraine prompts us to communicate briefly our experience with this drug as a therapeutic agent in headache. Attracted by the idea that a volatile medicament might offer a simple means for the prompt relief of headache, we tried trichlorethylene on a small group of patients in February 1936. We selected this drug because of the reports of occasional success with it in the relief of trigeminal neuralgia and angina pectoris.Trichlorethylene was supplied by the Calco Chemical Company in glass pearls containing 1 cc. of the substance. In the treatment a pearl would be crushed in gauze, placed in the bottom of a drinking glass, and the vapor inhaled by the patient. If relief was not obtained from the first ampule within fifteen


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