May 1, 1937, Vol 108, No. 18 >

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ANTIPNEUMOCOCCUS RABBIT SERUM AS A THERAPEUTIC AGENT IN LOBAR PNEUMONIA

F. L. HORSFALL, M.D.; KENNETH GOODNER, Ph.D.; C. M. MacLEOD, M.D.; A. H. HARRIS, M.D.

JAMA. 1937;108(18):1483-1490. doi:10.1001/jama.1937.02780180007003.

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Antipneumococcus serum is at present the only specific therapeutic agent useful in the treatment of lobar pneumonia. The first conclusive evidence of the effectiveness of specific serum in type I pneumococcus pneumonia was brought by studies made in the Hospital of the Rockefeller Institute in 1912-1913.¹ During the twenty-four years since the publication of this report the value of type I antipneumococcus serum has been conclusively proved by studies in this hospital,² and these results have been confirmed and extended by numerous workers.³

In type II pneumococcus pneumonia the value of antipneumococcus serum is somewhat less definite, but the reports of Bullowa,⁴ Cecil and Plummer,⁵ Finland and Sutliff⁶ and Finland and Dowling⁷ indicate that the mortality rate may be reduced by the early administration of adequate amounts of serum.

The results of specific serum therapy in type VII and type VIII pneumococcus pneumonias

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HORSFALL FL, Jr., GOODNER K, MacLEOD CM, HARRIS AH, 2D. ANTIPNEUMOCOCCUS RABBIT SERUM AS A THERAPEUTIC AGENT IN LOBAR PNEUMONIA. JAMA. 1937;108(18):1483-1490. doi:10.1001/jama.1937.02780180007003.

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