We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |


JAMA. 1937;108(17):1435-1436. doi:10.1001/jama.1937.02780170053017.
Text Size: A A A
Published online


The anaerobe Vibrion septique produces a specific toxin that causes striking effects when inoculated intravenously into laboratory animals. This toxin is unusual in the rapidity of its action, especially on rabbits. A recent study of the gross and microscopic changes produced by the toxin in animals has been reported by Pasternack and Bengtson.1 The animals used were rabbits, mice, guinea-pigs and pigeons; the results of the studies on these animals disclose certain facts that appear important in understanding the pathologic physiology of fatal human "gas" gangrene due to this organism.

The toxin of Vibrion septique has powerful cardiotoxic properties if not even a special affinity for the heart. This organ in almost all animals that survive any length of time shows lesions of some character. Intense capillary engorgement, conglutination and fusion of the red blood cells and occasionally hyaline thrombi are commonly noted. Scattered focal interstitial hemorrhages and some


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.