0
November 17, 1945, Vol 129, No. 12 >
Other Articles | November 17, 1945

FAILURE OF CHOLINE CHLORIDE TO AUGMENT ANEMIA IN CIRRHOSIS OF THELIVER

Janet Watson, M.D.; W. B. Castle, M.D.
JAMA. 1945;129(12):802-803. doi:10.1001/jama.1945.92860460002007a.
Text Size: A A A
Published online
Article
References

The report by Davis1 of the production of hyperchromic anemia in dogs by the administration of choline chloride is of considerable interest in view of the increasing use of this substance in the treatment of liver disease in man.2 Cartwright and Wintrobe3 recently gave choline chloride to 3 men over a period of ninety days without any hematologic effect. However, since none of their patients was suffering from hepatic disease, it seems worth while to report briefly a hematologic study of the effect of choline in a patient with cirrhosis of the liver and macrocytic anemia.

Davis1 produced anemia in dogs by giving choline chloride orally in a dose of 10 mg. per kilogram of body weight daily for at least twenty-five days. When a definite anemia was established, the dosage was successively increased to 20 and 30 mg. per kilogram. There was said to be a

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Letters

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs

More Listings at
JAMACareerCenter.com >

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems