We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |

Current Comment

JAMA. 1945;129(9):620. doi:10.1001/jama.1945.02860430036013.
Text Size: A A A
Published online


STREPTOMYCIN AND PROMIN IN EXPERIMENTAL TUBERCULOSIS  Guinea pigs infected with tuberculosis were employed by Smith and McClosky1 to determine whether streptomycin has any beneficial effect, to compare the results of streptomycin therapy with the sulfone promin and to explore the possibilities of combined treatment with these two cheniotherapeutic agents. Under the experimental conditions of treatment streptomycin injected intramuscularly produced a definitely greater chemotherapeutic effect than promin. The dose of promin used was about one-half the maximum tolerated dose, while the dose of streptomycin used was less than one twentieth of its maximum tolerated dose; hence streptomycin had a therapeutic index at least ten times that of promin. Neither of these agents used alone completely eradicated the tuberculous process. Larger doses and better methods of administration may well increase the therapeutic effect of streptomycin. By the application of a suitable combination of promin and streptomycin, Smith and McClosky obtained results


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.