Low sodium chloride dietary intake has been attempted in the treatment of epilepsy, migraine, Ménière's syndrome, hypertension, cardiac insufficiency and certain renal conditions with considerable success. In the treatment of epilepsy it has generally been regarded as efficacious in increasing the therapeutic effectiveness of bromides, while a number of authors have maintained that increased salt intake increases the frequency of convulsive seizures. In earlier dietetic literature, Friedenwald and Ruhräh,1 for instance, in their discussion of the role of restricted salt intake, refer to past empirical clinical observations in which such a regimen was noted to have benefited certain "extremely nervous and irritable individuals."
Delaville and Tscherniakofsky2 investigated the chloride content of the brains of a group of mental patients at autopsy and found increased chloride retention in most of these, thus suggesting the possibility of some relationship between certain mental disorders and chloride metabolism.
Von Noorden3 noted