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Paget's Disease of the Nipple and Its Relation to Surface Cancers and Precancerous States in General

JAMA. 1937;108(9):756. doi:10.1001/jama.1937.02780090068033.
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This book is a valuable archive of detailed reports of cases of Paget's disease together with excellent and beautiful gross pathologic and histologic illustrations. On the basis of his carefully examined material and a critical consideration of the literature, the author believes that Paget's disease is a special variety of cancer of the mammary ducts, beginning at the junction of the lactiferous duct with the epidermis and growing downward in the epithelium lining the duct wall of the acini as well as outward in the epidermis of the nipple. The most important difference between this disease and diseases that might produce similar changes in the squamous cell epithelium (as for instance Bowen's disease, Paget's disease in other parts of the body and precancerous lesions in the squamous cell epithelium of the mucous membrane of the upper respiratory tract or of the cervix) is that in these conditions the malignant cells


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