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DIFFUSE ADENOMATOSIS OF THE COLON

FRED W. RANKIN, M.D.; ALLEN E. GRIMES, M.D.
JAMA. 1937;108(9):711-715. doi:10.1001/jama.1937.02780090023007.
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Diffuse adenomatosis of the colon as a distinct clinical entity has been recognized for many years, but the histopathology revealing its malignant tendency has been a more recent contribution and has done much to alter modern views with regard to treatment. Menzel is credited by Warwick1 as having first called attention to the disease as such in 1721, and in 1832 Wagner2 described a condition which is now recognized as polyposis. Rokitansky in 1839 and Lebert in 1861 contributed to the knowledge of the condition. Luschka in the same year reported a case in which a woman, aged 30, was found to have thousands of polypi in the colon. "Colitis polyposa" was used by Virchow2 in 1863 in describing the lesions.

The tumors are usually multiple and widely distributed, often extending from the anus to the cecum, but having a tendency to appear approximately eight times more

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