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William E. Ehrich, M.D.; T. N. Harris, M.D.
JAMA. 1945;129(2):149. doi:10.1001/jama.1945.02860360051023.
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To the Editor:—  In a communication (July 7, p. 750) an editorial of The Journal (June 9, p. 442) was criticized for giving "the impression that only until recently has the origin of the globulins remained uncertain." According to Dr. Hobart A. Reimann, numerous investigators in the last fifty-three years have held the view that globulins originated in the leukocytes.We wish to point out that the literature referred to by Dr. Reimann (Reimann, H. A.; Medes, G., and Fisher, L.: The Origin of Blood Proteins, Folia hacmat.52:187, 1934) is not concerned with gamma globulins; it deals almost entirely with fibrinogen, which is now generally believed to be formed in the liver. Only two authors are quoted to have suggested that some globulins as well as fibrinogen were possibly produced by leukocytes, while one author believed that all plasma proteins arose from the disintegration of leukocytes and possibly


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