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JAMA. 1937;108(5):395-396. doi:10.1001/jama.1937.02780050051017.
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The development of accurate and rapid methods for the quantitative determination of vitamin C has led to extensive investigations of its biochemistry and physiology. Its solubility in water suggests the kidney as a pathway for the excretion of any vitamin C that might not be required by the organism. Numerous data have been obtained bearing on the variations in urinary vitamin C in health and disease. Correlation of these urinary analyses with clinical manifestations of scurvy has established the value of a study of the excretion of the vitamin as an aid in the detection of a deficiency. Thus it has been established1 that in normal persons the urinary excretion of cevitamic acid reaches levels that are proportional to the intake of the vitamin. Surprisingly little variation was found between individual normal subjects, the same daily dose of vitamin given to a number of persons producing after a time


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