The confusion that surrounds the subject of menstrual disorders is largely due to the fact that there has never been any adequate correlation of the symptoms, the endometrium and the underlying glandular disturbance. It is our purpose in this paper to attempt such a correlation. While dysmenorrhea has many points in common with the disorders of interval and flow, it has certain characteristics which set it apart from them, and we reserve it for a separate and later discussion. This paper is limited to the disorders of flow and interval.
In 1929 we began a series of studies on glandular cystic hyperplasia of the endometrium, and, as the results of these studies have been largely responsible for the opinions enumerated in this paper, it seems well to begin with a brief review of them. In our first experiments1 an analysis was made of the histologic changes produced in the