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George L. Waldbott, M.D.
JAMA. 1937;108(1):63. doi:10.1001/jama.1937.02780010073023.
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To the Editor:—  In their article on "The Therapy of (Horse) Serum Reactions" in The Journal, Nov. 21, 1936, Fantus and Feinberg state that the symptoms of "accelerated serum sickness" are "similar to those described under serum sickness" and that "the manifestations may differ in no way from those previously described in serum sickness, but usually they are much more severe and alarming."Some authorities on this subject still confuse two entirely different phenomena; namely, allergic shock and serum sickness. The only symptom in common is urticaria and even this symptom is occasionally lacking. (Waldbott, G. L.: The Prevention of Anaphylactic Shock with a Study of Nine Fatal Cases, The Journal, Feb. 6, 1932, p. 446.) Allergic shock is always the result of a previously existing sensitization, regardless of whether or not it is inherited or acquired, and is characterized only by allergic symptoms. This reaction is due to an


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