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Hamilton H. Anderson, M.D.; Daniel Delprat, M.D.; Alanson Weeks, M.D.; Alfred C Reed, M.D.
JAMA. 1936;107(26):2121-2123. doi:10.1001/jama.1936.92770520002008b.
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Although polyposis of the colon is not uncommon and malignant transformation is known to occur,1 the etiology of polyps is still a matter of conjecture. In fact, we seem no closer to the solution of this problem than Wagner2 was in 1832 when he "described the formation during the healing process of pedunculated polypoid, little warts on the margins of the ulcers and on certain smooth patches on their surface." He evidently did not suspect, however, that the warts were really folds of the diseased mucous membrane itself.3 Irregular, polypoid masses of mucosa are often found at the margins of ulcers in the process of healing or are formed by the undermining of part of the mucosa in cases of chronic dysentery and chronic ulcerative colitis. Woodward3 terms this pathologic entity "pseudopolyposis of the colon," thus distinguishing it from the colonic tumors of idiopathic origin referred to by Virchow.


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