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JAMA. 1936;107(21):1688-1693. doi:10.1001/jama.1936.02770470006002.
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Carcinoma of the colon is a very common lesion, which occurs at all ages. In approximately 50 per cent of all cases encountered the disease has advanced beyond hope of surgical relief. There is an operative mortality varying from 5 to 35 per cent. Frequently the recovery of the patient is stormy, and in lesions of the rectum and lower part of the colon there is all too often the mutilation and social isolation associated with permanent colostomy. In growths more proximally situated, the problem of colostomy is avoided but the frequency of recurrence is greater. Metastasis to the liver and to regional lymphatic channels is always a specter which haunts the lives of those individuals fortunate enough to survive operation. The outlook for a patient proved to have even an operable carcinoma of the colon is, to say the most, not greatly encouraging.

This statement is true despite the


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