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RECURRENT PNEUMOCOCCIC MENINGITIS FOLLOWING SULFONAMIDE THERAPY

Daniel H. Labby, M.D.
JAMA. 1945;127(15):981-984. doi:10.1001/jama.1945.92860150004006.
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Pneumococcic meningitis in the past has been an extremely fatal condition, a review of cases recorded before 1937 revealing only 185 cures in the entire literature.1 This discouraging situation has been greatly modified by the use of chemotherapeutic agents. The wise use of sulfonamides early in pneumococcic pneumonia and other pneumococcic infections has prevented an undetermined number of meningeal complications, and the intensive use of these drugs has resulted in many apparent cures of well established pneumococcic meningitis. In addition it appears that occasionally the use of sulfonamide drugs may result in arrest of meningeal manifestations without cure, and that temporary remissions may be followed by relapses displaying typical signs of meningitis of greater or less severity. This relapsing form of pneumococcic meningitis may be regarded as a new clinical phenomenon which has thus far been reported in only 3 cases2 and in each instance after more

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