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JAMA. 1945;127(8):460. doi:10.1001/jama.1945.02860080032010.
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Dangers encountered in the administration of large amounts of salicylates recently have been reported. Salicylates have long been usedin the treatment of rheumatic fever. Physicians are familiar with the astonishing relief the drug gives the stricken child. Acutely inflamed joints that are so sensitive that they cannot tolerate the weight of the bedclothes soon are able to resume their normal function after the administration of salicylates. The antipyretic properties of the drug are as striking as are the analgesic effects.

Recently Coburn1 advocated the administration of large doses of salicylates in acute rheumatic fever. He recommended the intravenous administration of 10 Gm. of sodium salicylate in 1,000 cc. of 0.9 per cent sodium chloride every day for four days. Intravenous medication was given slowly over a period of four to six hours, so that sufficiently high concentrations of the drug in the body could be reached and maintained. Plasma


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