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JAMA. 1944;126(17):1089. doi:10.1001/jama.1944.02850520031016.
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VISCERAL REACTIONS TO ANOXIA  The occurrence of myocardial necrosis and calcification in dogs subjected to tourniquet shock1 or histamine shock2 attracts attention once more to the visceral reactions following anoxic episodes of varying duration affecting the heart, aorta, brain, testes and bone marrow. Similar degeneration, necrosis and fibrosis of the myocardium have been observed in man and in animals after poisoning with epinephrine, nicotine, digitalis glycosides, parathyroid injection, vitamin D, nitrites, carbon monoxide, carbon disulfide and reduced oxygen pressure and also after excessive physical labor. The lytic necrosis with cyst formation in the media of the ascending aorta of man after burn shock, of dogs after histamine shock and of rabbits following the injection of epinephrine are evidently also of anoxemic genesis. Focal softenings and gliosis of the brain often located in the basal ganglions and giving rise to parkinsonism have been observed in man and animals after


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