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THE USE OF THEOPHYLLINE ETHYLENEDIAMINE (AMINOPHYLLINE) FOR THE RELIEF OF BILIARY COLIC: A PRELIMINARY REPORT

Arthur Gladstone, M.D.; Louis Goodman, M.D.

JAMA. 1944;126(17):1084-1085. doi:10.1001/jama.1944.82850520001010.

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Our purpose in this communication is to call attention to the use of theophylline ethylenediamine for the relief of biliary colic. For many years it has been known that the xanthines are capable of relaxing certain smooth muscles. Thus, theophylline has been employed for symptomatic relief of patients with angina pectoris and bronchial asthma.¹ The antispasmodic action of theophylline, however, is not manifested to any great extent on the gastrointestinal tract. Nevertheless, it has been shown by Butsch, McGowan and Walters² that theophylline ethylenediamine is effective in overcoming spasm of the biliary tract produced in man by the injection of morphine, dihydromorphinone hydrochloride (dilaudid) or codeine. It is well known that the phenanthrene alkaloids of opium produce spasm of smooth muscles of hollow viscera. Morphine relieves pain due to such spasm only by virtue of its analgesic action on the central nervous system. Locally, the mechanism for the

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Gladstone A, Goodman L. THE USE OF THEOPHYLLINE ETHYLENEDIAMINE (AMINOPHYLLINE) FOR THE RELIEF OF BILIARY COLIC: A PRELIMINARY REPORT. JAMA. 1944;126(17):1084-1085. doi:10.1001/jama.1944.82850520001010.

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THE USE OF THEOPHYLLINE ETHYLENEDIAMINE (AMINOPHYLLINE) FOR THE RELIEF OF BILIARY COLIC: A PRELIMINARY REPORT

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