We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |


Arthur Gladstone, M.D.; Louis Goodman, M.D.
JAMA. 1944;126(17):1084-1085. doi:10.1001/jama.1944.82850520001010.
Text Size: A A A
Published online

Our purpose in this communication is to call attention to the use of theophylline ethylenediamine for the relief of biliary colic. For many years it has been known that the xanthines are capable of relaxing certain smooth muscles. Thus, theophylline has been employed for symptomatic relief of patients with angina pectoris and bronchial asthma.1 The antispasmodic action of theophylline, however, is not manifested to any great extent on the gastrointestinal tract. Nevertheless, it has been shown by Butsch, McGowan and Walters2 that theophylline ethylenediamine is effective in overcoming spasm of the biliary tract produced in man by the injection of morphine, dihydromorphinone hydrochloride (dilaudid) or codeine. It is well known that the phenanthrene alkaloids of opium produce spasm of smooth muscles of hollow viscera. Morphine relieves pain due to such spasm only by virtue of its analgesic action on the central nervous system. Locally, the mechanism for the


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.