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THE EFFECT OF PARA-AMINOHIPPURIC ACID ON PLASMA CONCENTRATION OF PENICILLIN IN MAN

KARL H. BEYER, Ph.D., M.D.; HARRISON FLIPPIN, M.D.; W. F. VERWEY, D.Sc.; ROLAND WOODWARD, B.S.
JAMA. 1944;126(16):1007-1009. doi:10.1001/jama.1944.02850510015003.
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Since the original announcement by Beyer, Peters, Woodward, Verwey and Mattis1 three reports have been submitted for publication or appear in the literature to the effect that when sodium para-aminohippurate and penicillin were administered simultaneously the former compound competed with penicillin for the same renal tubular excretory mechanism. By doing so the rate of renal elimination of penicillin was much reduced, thereby slowing considerably the rate of fall of the plasma concentration of the antibiotic agent.2 It was shown further that, in experiments wherein penicillin was administered continuously at a given rate for as long as forty-eight to fifty-four hours, raising or lowering the plasma concentration of para-aminohippuric acid similarly administered produced a concomitant elevation or fall of the plasma concentration of penicillin. A combination of these agents was administered continuously by venoclysis for forty-eight hours to dogs without producing functional or histomorphologic changes attributable to the two

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