PARIS

Use of Pancreatic Extracts in the Treatment of Angina Pectoris  Several observers had noted that injections of insulin sometimes cause marked improvement in patients with angina pectoris. But the results of such treatment were annoyingly variable. This fact gave rise to the idea that the effects might be due not to the insulin itself but to some other substance associated with it and brought in through the preparation of that complex product. Pierre Gley and V. Kisthinos have succeeded in isolating from pancreatic extracts a substance lacking a glycolytic action—which is not a peptone, a choline, or a histamine, and which crude insulin extracts contain in varying proportions. When injected into an animal, it produces a manifest and rapid hypotensive action. It arrests frankly the hypertensive action of an injection of epinephrine. The effects of the substance are measured by taking as the standard a quantity which, when injected suddenly