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JAMA. 1929;93(18):1367-1369. doi:10.1001/jama.1929.02710180017006.
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Argyrosis of the conjunctiva is not an uncommon condition and usually follows prolonged local medication with silver nitrate or colloidal silver compounds, principally mild silver protein. Up to the present time there has been no successful method of removing the objectionable color which is present in argyrosis of the conjunctiva.

In conjunctival argyrosis there is a precipitate of silver albuminate and of silver oxide in the subconjunctival tissue. Fuchs1 shows that the epithelium is unaffected but that the elastic fibers appear to contain brown punctate granules and there are a few extrafibrillar granules. He states that the silver is present as an organic compound. Gettler, Rhoads and Weiss2 describe the silver particles in the skin as being found in the elastic fibers and the collagen fibers, but none are intracellular. It would seem that as the conjunctiva is exposed to light, in the same manner as is a


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