In 1923 I became interested in periodic health examinations and determined, for my own satisfaction, to discover whether or not they were of use. I believe that the periodic health examination method should be regarded seriously by the man in general practice as an important tool for clinical investigation. In light of present knowledge so little is known of the mode of origin of many diseases that to expect the periodic health examination to be very useful in preventive medicine is unsound. But it affords every doctor an opportunity to observe patients systematically over long intervals of time and thereby enables him to add new bits of medical knowledge.
To explore this idea further I have assembled a small group of patients with toxic goiter studied by this method. My attempt here is to give a narrative of this disturbance as an actual experience in their life cycle. My material