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August 31, 1929, Vol 93, No. 9 >
ARTICLE | August 31, 1929

THE STATUS OF THE THERAPEUTICS OF IRRADIATED ERGOSTEROL

ALFRED F. HESS, M.D.; J. M. LEWIS, M.D.; HELEN RIVKIN, B.A.
JAMA. 1929;93(9):661-665. doi:10.1001/jama.1929.02710090001001.
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Somewhat more than three years has passed since Windaus and Hess, as well as Rosenheim and Webster, reported the remarkable antirachitic activity of irradiated ergosterol. During this short interval a considerable literature has sprung up, regarding both the theoretical and the clinical aspects of this subject. It would be to no purpose to review the numerous papers that have been published abroad and in this country treating of the clinical value of this new preparation. A complete bibliography will be found in the recent articles by Karelitz,1 by György2 and by Wieland.3

All are agreed that irradiated ergosterol is an agent of exceptional potency and reliability in the prevention or the cure of rickets. The time is past for a discussion of this point. There are, however, several questions which demand consideration at the present time. One that has been raised repeatedly concerns the safety of this

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