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Milton Kissin Major, M. C.
JAMA. 1944;125(12):866. doi:10.1001/jama.1944.02850300046021.
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To the Editor:—  In the May 13 issue of The Journal is an article by Elder and Harrison on the prevention of pentothal sodium slough with procaine hydrochloride. They stated that there had been no opportunity to test the method in man, and the suggestion is made that the method might be useful in preventing slough caused by the extravenous injection of other irritants.In 1931 I was privileged to spend several weeks with the late Dr. Soma Weiss, who at that time was at the Thorndike Memorial of the Boston City Hospital. He was working with Dr. George Robb and Dr. Lawrence Ellis on the sodium cyanide circulation time. As an experimental subject I was given an injection of sodium cyanide solution, which through accident was deposited outside the vein. Dr. Weiss immediately injected 1 per cent procaine hydrochloride solution, which gave prompt relief from the intense pain. No


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