Oxyl iodide has been on the market for about six years, and is used, like cinchophen, in the treatment of chronic arthritis, neuritis and myositis. It is said to contain "one part of iodine to five parts of phenylcinchoninic acid, two parts of the latter in chemical union with one part of iodine." The drug is a mixture of two parts of cinchophen chemically combined with one part of iodine and three parts of uncombined cinchophen; that is, 83.3 per cent cinchophen and 16.7 per cent iodine.
Cinchophen has been used as a therapeutic agent for about twenty years. Since 1923, an increasing number of reports have appeared in medical literature which suggest the possibility that cinchophen and its derivatives and combinations may induce a very severe toxic jaundice in some patients.
Worster-Drought,1 Brown,2 Evans,3 Glover,4 Willcox,5 Kingreen,6 Hitzenberger,7 Schwarz,8 Haudek,9