Victor Goodhill, M.D.
JAMA. 1944;125(1):28-30. doi:10.1001/jama.1944.72850190002009b.
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A 5 year old boy with acute fulminating bilateral cavernous sinus thrombophlebitis made a complete recovery when treated with penicillin,1 after showing no response to sulfonamideheparin therapy.

Thrombophlebitis of the cavernous sinus is one of those diseases the mortal aspect of which has cast an ominous shadow over infections of the face and head. Prior to the advent of sulfonamide therapy, reports of recovery and "cure" of this disease were rare.

When sulfonamides were first introduced, isolated cases of recovery began to appear. The addition of heparin to sulfonamide therapy further improved the statistics for survival in this previously highly fatal disease.

The present case is interesting in that (1) no response was noted following therapy with heparin and sulfathiazole and (2) prompt clinical response followed therapy with penicillin.


History.—  E. A., a 5½ year old Mexican boy, had a "pimple" on his forehead on


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