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July 6, 1929, Vol 93, No. 1 >
ARTICLE | July 6, 1929

THE STABILITY OF DIGITALIS AND ITS PREPARATIONS

HARVEY B. HAAG, M.D.; ROBERT A. HATCHER, M.D.
JAMA. 1929;93(1):26-29. doi:10.1001/jama.1929.02710010032007.
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Many have sought to determine the cause of deterioration in preparations of digitalis, and the discovery of one or more factors that are concerned in the deterioration has caused certain manufacturers to claim complete stability for their preparations. The accumulation of a large number of specimens of digitalis leaf and preparations of many types, some of which have been standardized during the past twenty years, afforded us an opportunity for making a comparison of the rate of deterioration in a wide variety of these preparations.

A few references to the literature will suffice to indicate prevalent opinions and we shall then present only those results of our experiments which are of practical interest in therapeutics, leaving the details of the experiments to be published elsewhere. All our tests of activity, except a few with rapidly eliminated fractions, were made by the method described by Hatcher and Brody.1

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