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June 22, 1929, Vol 92, No. 25 >
ARTICLE | June 22, 1929

THE ACIDOSIS. OF PREGNANCY

JAMA. 1929;92(25):2104. doi:10.1001/jama.1929.02700510034014.
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The acidosis of pregnancy has long been a puzzle to students of obstetrics and biochemistry. This does not refer to extreme abnormalities such as are characterized by pernicious vomiting or eclamptic manifestations but rather to the well established phenomena of normal pregnancy. The existence of a lowered alveolar carbon dioxide tension has been known many years. The reduction in the alkali reserve in pregnancy has been described by numerous observers, one of whom has alleged that he detected a lowered plasma carbon dioxide combining power as early as three days following the first missed menstrual period.

As Oard and Peters1 of Yale University School of Medicine have pointed out, a reduction of the blood alkali reserve may be the result of one or the other or of a combination of both of two factors; namely, an unusual collection of acid in the blood, or a reduction of the fixed

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