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THE STATUS OF INTRAVENOUS THERAPY

REID HUNT, M.D.; WILLIAM S. McCANN, M.D.; L. G. ROWNTREE, M.D.; CARL VOEGTLIN, Ph.D.; CARY EGGLESTON, M.D.
JAMA. 1929;92(25):2099-2101. doi:10.1001/jama.1929.92700510003010.
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VI. THE INTRAVENOUS USE OF GLANDULAR PRODUCTS  A careful consideration of the actual indications for the intravenous use of drugs and of the nature of glandular products and of their action in the body would seem to indicate that their injection directly into the vein is seldom, if ever, necessary or justifiable.The subcutaneous administration of drugs has been used in practice for many years. Relatively speaking, it is a familiar field. Drugs so administered are, as a rule, more rapidly absorbed and exert a more rapid and powerful effect than when given by mouth. But their hypodermic use has necessitated a nice adjustment in relation to refinement of the drugs and the dose to be employed. Even so, one frequently sees evidence of the overaction of drugs when so administered. With intravenous use, the body is instantaneously and irrevocably exposed to the sudden action of the drug, and calamitous results cannot be avoided at times except

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