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June 22, 1929, Vol 92, No. 25 >
ARTICLE | June 22, 1929

AGRANULOCYTOSIS WITH RECOVERY

Wyndham B. Blanton, M.D.
JAMA. 1929;92(25):2099. doi:10.1001/jama.1929.92700510003009b.
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ABSTRACT

Agranulocytosis is still uncommon enough to excite interest, in spite of the fact that more than fifty cases have been reported since Shultz described the syndrome in 1922. The disease usually begins abruptly with sore throat, fever, chilly sensations, aches and prostration. The physical abnormalities are typically (1) a bleeding ulceration of the mouth with a membrane often simulating that of diphtheria; (2) enlargement of the liver and spleen; (3) occasional swelling of the inguinal lymph glands, and (4) ecchymosis and herpes. The blood count shows a marked leukopenia, often less than 1,000 white cells being present. The polymorphonuclear series is chiefly affected, the proportion of these cells often falling to 1 or 2 per cent. Since more than 90 per cent of the reported cases have proved fatal, it is thought worth while to record one in which recovery took place.

REPORT OF CASE 

History.  —A man, aged

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