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ARTICLE |

ALLERGIC PURPURA

H. L. ALEXANDER, M.D.; C. H. EYERMANN, M.D.
JAMA. 1929;92(25):2092-2094. doi:10.1001/jama.1929.02700510022006.
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In a previous article, we1 called attention to the occurrence of allergy with Henoch's purpura and cited three cases in which this association existed. During the past two years, six similar cases have been observed. In all a "food allergy" was demonstrated. By deliberate feeding of the offending allergens, hemorrhage into the skin and usually one or more of the accompanying symptoms and signs of Henoch's purpura could be demonstrated. These included abdominal pain, joint inflammation, urticaria and bleeding from mucous membranes. An associated nephritis was present in only one case.

The natural history of Henoch's purpura has always presented a varying picture which has made its etiology baffling. Osler,2 who took a particular interest in the condition, reported some series of cases over a period of nineteen years. He stressed particularly the association of skin lesions and visceral symptoms. Purpura, urticaria angioneurotic edema and erythema multiforme comprised the erythema

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