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THE FILTRABLE ELEMENTS OF THE TUBERCULOSIS VIRUS (TUBERCULOUS ULTRAVIRUS)

A. CALMETTE; J. VALTIS; A. SAENZ
JAMA. 1929;92(25):2086-2088. doi:10.1001/jama.1929.02700510016003.
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Numerous researches in the last few years have confirmed the hypothesis put forward by Fontes in 1910 regarding the filtrability of the tuberculosis virus, and have revealed the existence in cultures of the tubercle bacillus, as well as in tuberculous lesions, of certain elements which can pass through porous porcelain filters and produce in guinea-pigs lesions of a special type, as is evidenced by the fact that guinea-pigs inoculated with tuberculous filtrates never show (even after a survival of from six to eight months) an inoculation chancre with its satellite caseous adenitis, or the nodular visceral lesions which are generally obtained through the inoculation of tuberculous products. On the other hand, the glands in the vicinity of the point of inoculation become slightly swollen from the tenth to the fifteenth day and subsequently become normal again. Autopsies of animals having died from an intercurrent disease, or as the result of

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