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June 1, 1929, Vol 92, No. 22 >
ARTICLE | June 1, 1929

ACUTE THROMBOCYTOPENIC PURPURA CURED BY SPLENECTOMY

W. A. Killins, M.D.
JAMA. 1929;92(22):1832-1833. doi:10.1001/jama.1929.92700480001010.
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Immediate and lasting relief from hemorrhage has followed the removal of the spleen in cases of chronic hemorrhagic purpura. It has been said that at operation hemorrhage has actually been seen to stop as soon as the pedicle of the spleen is clamped. Because equally dramatic cessation of bleeding followed the operation in an acute case of this disease which I saw recently, this report is made.

Thrombocytopenic purpura is an acute or chronic disease characterized by a marked diminution in the number of blood platelets, spontaneous hemorrhages from mucous membranes, and purpura. It was first differentiated from other forms of hemorrhagic disease by Werlhof in 1781 and is sometimes called Werlhof's disease. Since Kaznelson performed the first splenectomy for chronic hemorrhagic purpura in 1916, this procedure has become the standard treatment for this type of the disease. In 1925, Giffin and Halloway1 collected reports of all the cases of

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