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May 11, 1929, Vol 92, No. 19 >
ARTICLE | May 11, 1929

ATROPINE FEVER

JAMA. 1929;92(19):1602. doi:10.1001/jama.1929.02700450034013.
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Almost all substances that are employed as therapeutic agents have shortcomings or "by-effects" that need to be taken into consideration along with the desired pharmacologic responses they elicit. Among these, atropine is no exception. Indeed, the changes that it can develop in the organism are so manifold that the alkaloid is employed in medicine for a number of seemingly unrelated purposes; and under these conditions an undesired reaction may be tolerated for the sake of securing a quite different simultaneous response. Thus the suppression of secretion by the drug may be the chief end sought in a given case, whereupon the mydriatic effect is tolerated as an inevitable concomitant possibility. Both these reactions may become incidents of the administration of atropine to abolish spasm of the muscles of the alimentary tract. Accordingly, the use or abandonment of the drug, or the dosage recommended, may depend on a balancing of desired

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