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May 4, 1929, Vol 92, No. 18 >
ARTICLE | May 4, 1929

IRRADIATED ERGOSTEROL

J. Clifford Hoyle
JAMA. 1929;92(18):1542. doi:10.1001/jama.1929.02700440050032.
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ABSTRACT

To the Editor:  —In his article on the effects of massive doses of irradiated ergosterol (The Journal, February 23), Klein makes no reference to the work of Dixon and myself (Brit. M. J. 2:832 [Nov. 10] 1928), so that it would perhaps be worth pointing out in your columns that Dr. Klein's results confirm ours and are opposed to those of the German workers. Neither in our experiments nor in those of Dr. Klein, apparently, were lethal effects noted, and this is entirely at variance with the German results. Dr. Klein does not report the postmortem observations in his animals, which is unfortunate in view of the fact that here also our results differed wholly from those of the German workers. Moreover, he does not state in what solvent the ergosterol which he used was irradiated. From the work of Dixon and Hoyle this may well be a crucial

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