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April 13, 1929, Vol 92, No. 15 >
ARTICLE | April 13, 1929

HYPERVITAMINOSIS

JAMA. 1929;92(15):1270-1271. doi:10.1001/jama.1929.02700410040015.
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From data relating to the therapeutic potency of irradiated ergosterol in protecting experimental animals against rickets on an otherwise rachitic diet, it has been estimated that one part in many millions of food suffices to secure the prophylactic purpose. In human infants a daily dosage of considerably less than 4 mg. (6/100 grain) has already been demonstrated to be curative in cases of unmistakable rickets; and there is little doubt that this quantity may be considerably larger than the minimal protective dose. It should not be surprising, therefore, if larger quantities of such potent substances would exert a pronounced effect on the organism in directions that may not always be merely beneficial. Pharmacology is replete with instances of baneful and of beneficial results arising from exhibition of the same drug, the outcome depending on dosage. Small doses of highly toxic alkaloids are used as remedial measures in medical practice. The

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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