AGRANULOCYTIC ANGINA FOLLOWING PROPHYLACTIC TYPHOID VACCINATION

In a survey of the literature from the first description of agranulocytic angina by Schultz¹ in 1922 up to December, 1928, we have found a total of 152 cases conforming in general to the clinical criteria that he outlined. Although the etiology of the disease is entirely unknown, most observers are agreed that the marked reduction or total absence of granular leukocytes, which is the remarkable finding common to all cases, occurs as a result of some obscure septic or toxic bone marrow depressant. We have recently observed a case showing abnormal reaction of the hematopoietic system which occurred so directly after prophylactic injections of typhoid vaccine as to suggest that this may have been the toxic agent that incited the clinical manifestations of agranulocytic angina. This is a circumstance previously unmentioned in the literature.

REPORT OF CASE  E. W. L., a white woman, aged 50, entered the Jewish Hospital