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March 16, 1929, Vol 92, No. 11 >
ARTICLE | March 16, 1929

NATURE AND TREATMENT OF THE TOXEMIA OF INTESTINAL OBSTRUCTION AND ILEUS

CHARLES S. McVICAR, M.D.; JAMES F. WEIR, M.D.
JAMA. 1929;92(11):887-892. doi:10.1001/jama.1929.02700370035010.
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Our purpose in this paper is to report a study made on patients suffering from the effects of intestinal obstruction and ileus. Our observations include illustrative abstracts of the clinical manifestations, chemical changes in the blood, and reactions to treatment in a comprehensive series of cases. During the last six years we have worked in constant association with our surgical colleagues in the management of patients showing inhibition of gastro-intestinal motor function. The experience gained has prompted us to make certain deductions regarding the nature of the peculiar toxemia associated with motor inhibition.

We shall not attempt to discuss the literature dealing with experimental or clinical studies of obstruction. The widespread interest in the subject is indicated by the articles that have appeared.1 Experimental studies have for the most part been designed to determine the cause of death. While it is eminently desirable that the cause of death in

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