We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


Ferdinand C. Helwig; Edward D. Freis
JAMA. 1943;123(10):626-628. doi:10.1001/jama.1943.82840450001007.
Text Size: A A A
Published online


The phenomenon of autoagglutination and autohemolysis has often been described in paroxysmal hemoglobinuria, which is sometimes encountered in congenital syphilis. In 1937 McCombs and McElroy1 in a review of the available literature reported that autoagglutination had been observed in hemolytic icterus, trypanosomiasis,2 severe anemias and liver disease, occasionally in pneumonia and also in apparently normal persons. It has likewise been reported in cases of hemolytic anemia associated with sulfanilamide therapy3 and acute hemolytic anemia due to lead poisoning.4 Wiener5 in his recently revised book on "Blood Groups and Transfusions" expressed the thought that the phenomenon must not be too rare because he himself had observed at least a dozen instances of autoagglutination occurring at room temperature.

In February 1943 Peterson, Ham and Finland6 reported finding a high incidence of cold agglutinins (autohemagglutinins) which appeared at low temperatures in the blood serum of patients with


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.