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February 16, 1929, Vol 92, No. 7 >
ARTICLE | February 16, 1929

Études sur les nævi pigmentaires de la peau humaine (melanoblastomes bénins).

JAMA. 1929;92(7):583. doi:10.1001/jama.1929.02700330067038.
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ABSTRACT

Some of the author's first published results from working with the dermatologist Bruno Bloch of Zurich, in 1918, appeared in the British Journal of Dermatology and Syphilis in 1920, and in this monograph they are elaborated. They all deal with the method which bears Bloch's name of demonstrating microscopically the presence in certain cells of an oxidizing enzyme supposed to be tyrosinase. Use is made of 3, 4 dioxyphenylalanin, a compound with its name now shortened to dopa, and the test has been known now for several years as Bloch's dopareaction. Kissmeyer has studied the nature of the reaction carefully and determined the optimal ph at which it occurs. Applying it to a study of nevi and to many other conditions in which the skin is pigmented, he has accumulated a great deal of evidence that the staining which results in certain cells is specific for epithelial cells, and

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