0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

THE DRUG TREATMENT OF MALARIA, SUPPRESSIVE AND CLINICAL

JAMA. 1943;123(4):205-208. doi:10.1001/jama.1943.82840390004007.
Text Size: A A A
Published online

1. Efficacy of Atabrine, Quinine and Plasmochin.—  a. Available evidence indicates that atabrine is as effective as quinine (or more so), both in suppressive use and in the treatment of clinical attacks. No available drug or plan of administration can be expected to prevent relapses in all cases (see paragraph 6). Recent studies have shown that the plasma level of the drug is fundamental in determining its efficacy. Under ordinary conditions the rates of absorption of the two drugs are not significantly different. Quinine is localized in the tissues to a smaller extent than atabrine, and effective plasma concentrations, therefore, are usually attained shortly after the beginning of its administration. Atabrine, on the other hand, at first is taken up to a much larger extent by the tissues, so that effective concentrations in the plasma are reached only as certain tissues become more or less saturated. On the usual

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();