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Richard C. Clay, M.D.; Kenneth L. Pickrell, M.D.
JAMA. 1943;123(4):203-204. doi:10.1001/jama.1943.82840390002006a.
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With the establishment of the bacteriostatic value of the different sulfonamides in various infections, it was a logical step to seek for a drug of this group which would control the normal and pathologic flora of the intestine. The fundamental requirements of such a drug were that it should be an effective bacteriostatic agent against coliform organisms in their natural habitat, that it should be so slightly absorbed that an adequate concentration in the bowel might be maintained, and that it should be nontoxic to the human organism. Marshall and his associates1 first introduced a drug appreciably water soluble but poorly absorbed, sulfanilylguanidine, and showed its clinical usefulness in bacillary dysentery. Subsequently Poth,2 Firor,3 and others introduced succinylsulfathiazole as an intestinal antiseptic and established the fact that in adequate dosage it lowered the coliform count of the stools significantly in over 90 per cent of cases in


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