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January 12, 1929, Vol 92, No. 2 >
ARTICLE | January 12, 1929

USE OF ALKALIS IN THE TREATMENT OF PEPTIC ULCER

LEON BLOCH, M.D.; A. M. SERBY, M.D.
JAMA. 1929;92(2):134-139. doi:10.1001/jama.1929.02700280038012.
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The advent of the Sippy method of ulcer management has raised the position of the use of alkalis to one of prime importance. The basic reason for their use, the accurate neutralization of the hydrochloric acid of the gastric juice and thereby the elimination of the corrosive action has, however, not been generally accepted as a fact. A large number of investigators and clinicians are not entirely convinced that the symptoms of peptic ulcer are the direct result of such corrosive action but, on the contrary, feel that the use of alkalis in amounts sufficient to effect a complete neutralization is not entirely free from danger. In 1923 Hardt and Rivers1 and later others2 described symptoms which were ascribed to the use of large doses of alkali and grouped under the terms alkalosis and toxic nephritis. High blood carbonates and an elevation of the nonprotein nitrogen of the

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