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January 12, 1929, Vol 92, No. 2 >
ARTICLE | January 12, 1929

LEAD THERAPY

LEILA CHARLTON KNOX, M.D.
JAMA. 1929;92(2):106-110. doi:10.1001/jama.1929.02700280010005.
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Blair Bell1 in 1925 called attention to the fact that certain cases of malignant disease had been arrested by the intravenous administration of colloidal lead. After study of the methods employed in Liverpool the treatment of a series of patients was begun at St. Luke's Hospital, New York, and it has been carried out during the last two years. In view of the interest in the method shown by the profession and by the public, this preliminary report is being made of our results.

Many of the patients received large doses of x-rays simultaneously with or subsequent to the administration of the lead. The reason for this was that Blair Bell had reported that the combination seemed useful and it also seemed unfair to the patients to deprive them of a remedy that had already been shown to have certain palliative or curative effects. X-rays were therefore given to

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