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January 5, 1929, Vol 92, No. 1 >
ARTICLE | January 5, 1929

THE INTRADERMAL TREATMENT OF ARGYRIA

ARTHUR WILLIAM STILLIANS, M.D.; THEODORE KENNETH LAWLESS, M.D.
JAMA. 1929;92(1):20-21. doi:10.1001/jama.1929.02700270024006.
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Since our1 discovery that a photographic reducing fluid, injected into the skin, removes deposits of silver, an opportunity has been given to put the method to a practical test. The patient mentioned in our preliminary report has been under treatment for several months. In our experimental work a patch of argyria was produced by the injection of mild silver protein into the skin of the arm, and a single injection of the reducing fluid into this patch produced a small light spot very little if at all different in color from the normal skin. We realized that this was not as rigid a test of the power of the injection as would have been afforded by an old, more heavily infiltrated patch of argyria, but the hope was expressed that as old negatives reduce well with this fluid, old cases of argyria would also prove amenable. This hope has

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