JAMA. 1928;91(26):2066. doi:10.1001/jama.1928.02700260032009.
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In an illuminating discussion of the much debated topic of acidosis before one of the sections at the Minneapolis session of the American Medical Association, Marriott1 remarked that acidosis and alkalosis as they occur in the body are merely symptoms of a general disturbance of equilibrium. Acidosis itself usually need not be worried about; for example, in chronic nephritis a certain degree of acidosis is probably desirable. If that acidosis did not exist in chronic nephritis, the patient would be in danger of developing tetany with convulsions. In certain other conditions, as, for example, mountain sickness, acidosis is normal or desirable and does not need treatment. It would not be advantageous to combat it but distinctly a disadvantage. Merely looking at the acidity of the urine or the ph of the blood or the bicarbonate of the blood is not a scientific procedure; the real underlying factor is


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